Ovarian serous carcinoma

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Overview

Two subtypes:[1]

Low grade serous carcinoma:

- 10% of ovarian serous carcinoma

- likely develop from ovarian serous borderline tumours

High grade serous carcinoma:

- 90% of ovarian serous carcinoma

- rapidly growing, highly aggressive

Aetiology

Associations/Risk factors

Epidemiology

Clinical features

Macroscopy

Microscopy

Low grade serous carcinoma:

- Mild to moderate nuclear atypia

- <12 mitoses per 12 high power fields

High grade serous carcinoma:

Molecular

Low grade serous carcinoma: - BRAF mutations

High grade serous carcinoma: - TP53 mutations - High levels of chromosomal instabiliy

Investigations

Management

Prognosis

References

  1. Ahn, G.; Folkins, AK.; McKenney, JK.; Longacre, TA. (Sep 2016). "Low-grade Serous Carcinoma of the Ovary: Clinicopathologic Analysis of 52 Invasive Cases and Identification of a Possible Noninvasive Intermediate Lesion.". Am J Surg Pathol 40 (9): 1165-76. doi:10.1097/PAS.0000000000000693. PMID 27487741.