Dysplasia of the Gallbladder

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Overview

Dysplasia within the gallbladder is usually an incidental finding, and is currently graded into low and high grade dysplasia. On finding dysplasia it is prudent to look for evidence of tumour on macroscopy and often to take additional blocks.

Aetiology

Associations/Risk factors

Epidemiology

Clinical features

Macroscopy

Microscopy

Investigations

Management

Prognosis

Advice

On finding incidental dysplasia of the gallbladder it is advised to examine additional blocks of the gallbladder. The formal advice as to what to do next varies:

  • Royal College of Pathologists: Low grade dysplasia warrants examining additional blocks. High grade dysplasia (or malignancy) warrants examination of the entire gallbladder.


  • Am J Surg Pathol. 2013; 140:278-280

Pyloric metaplasia: no additional blocks

Intestinal metaplasia: 2 additional blocks

Low grade dysplasia: 2 additional blocks

High grade dysplasia: 12 additional blocks

References

  • Tissue pathways for gastrointestinal and pancreatobiliary pathology, Royal College of Pathologists, UK, January 2016

https://www.rcpath.org/resourceLibrary/g085-tp-giandp-jan16-pdf.html

  • Am J Surg Pathol. 2013; 140:278-280